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Plagues and epidemics have ravaged humanity throughout its existence, often changing the course of history.

20 of the worst epidemics and pandemics in history

Before the discovery of Hamin Mangha, another prehistoric mass burial that dates to roughly the same time period was found at a site called Miaozigou, in northeastern China. wrote that "people in good health were all of a sudden attacked by violent heats in the head, and redness and inflammation in the eyes, the inward parts, such as the throat or tongue, becoming bloody and emitting an unnatural and fetid breath" (translation by Richard Crawley from the book "The History of the Peloponnesian War," London Dent, 1914). "The bowels, relaxed into a constant flux, discharge the bodily strength [and] a fire originated in the marrow ferments into wounds of the fauces (an area of the mouth)," Cyprian wrote in Latin in a work called "De mortalitate" (translation by Philip Schaff from the book "Fathers of the Third Century: Hippolytus, Cyprian, Caius, Novatian, Appendix," Christian Classics Ethereal Library, 1885). (Image credit: USGS) The infection that caused the cocoliztli epidemic was a form of viral hemorrhagic fever that killed 15 million inhabitants of Mexico and Central America. When citizens of Britain, France, Portugal and the Netherlands began exploring, conquering and settling the Western Hemisphere, they were also helped by the fact that disease had vastly reduced the size of any indigenous groups that opposed them. (Image credit: Shutterstock) The Black Death's last major outbreak in Great Britain caused a mass exodus from London, led by King Charles II. (Image credit: Shutterstock) When yellow fever seized Philadelphia, the United States' capital at the time, officials wrongly believed that slaves were immune. (Image credit: Otis Historical Archives, National Museum of Health and Medicine) An estimated 500 million people from the South Seas to the North Pole fell victim to Spanish Flu . A nurse walking by a triage tent set up outside of the emergency room at Sutter Delta Medical Center in Antioch, California on April 30, 2009. A smaller number of cases occurred in Nigeria, Mali, Senegal, the United States and Europe, the Centers for Disease Control and Prevention reported .

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